adrenal glands

Pregnenolone: What Is It, and What Are Its Benefits?

Pregnenolone: What Is It, and What Are Its Benefits? 1000 747 Abbe Lang

What is Pregnenolone?

Pregnenolone (preg-nen-o-lone) is a pre-hormone that is synthesized primarily by the adrenal glands. Pregnenolone has a minimal direct effect on the tissue itself, although it helps produce other hormones that do.  Because it acts as a pre hormone, Pregnenolone can also support low levels of the sex hormones estrogen, progesterone, and testosterone. 

Pregnenolone acts as a “mother” hormone to more than 50 additional adrenal hormones! 

Pregnenolone is the first hormone the adrenals create from cholesterol when the body is triggered by stress. Through a cascade of enzymatic action, Pregnenolone is converted into more active hormones, such as cortisol, DHEA, aldosterone, progesterone, etc.

What does it do?

Pregnenolone has been used experimentally for memory enhancement, improved stress tolerance, decreasing fatigue and increasing energy, muscle strength, and stamina, help with depression and anxiety, and more. 

Because it acts as a prohormone, Pregnenolone can also support low levels of all the sex hormones: estrogen, progesterone, and testosterone. 

Women have used it to assist fibrocystic breasts, symptoms of menopause, as well as PMS.

Historically it has also been used to treat allergies and autoimmune conditions, such as MS, lupus, and rheumatoid arthritis.

Like that of many steroid hormones, pregnancy production declines with age; by the time we’re 75 years old, we produce less than half of what we did at age 35. Some call this the result of aging; I call this the result of stress over time. Aging is simply the process of enduring the stress of our modern world.   

When a person takes supplemental Pregnenolone, it should enhance the conversion process to other hormones and contribute to the restoration of deficient hormones.

Benefits of Pregnenolone 

  • It makes you feel more alert by suppressing GABA and increasing glutamate. At the same time, this amazing hormone protects you from the negative effects of increased glutamate by increasing dopamine and protecting your hippocampal brain cells from the amyloid-beta protein,  the dominant protein associated with Alzheimer’s disease.
  • Increases your capacity for cognitive function by developing and supporting your hippocampus, the thinking center of the brain.
  • Helps generate new brain cells
  • Actively supports overall memory by increasing acetylcholine, the most dominant neurotransmitter associated with memory and cognitive function.
  • Increases spatial memory, which provides you with the ability to physically navigate from one place to another.
  • Increases memory in the aged, suggesting that it may reverse the effects of an aging memory.

Supplementation Research shows that pregnenolone supplementation benefits three major areas: the brain, adrenal health, and immunity. 


Some physicians feel pregnenolone is the key to your brainpower. Pregnenolone directly improves your cognitive function.

Adrenal Health 

Pregnenolone is considered an anti-stress hormone. Stress causes the body to produce less and utilize more Pregnenolone. For individuals who lead stressful lives, Pregnenolone protects the adrenal glands and helps to maintain balance. 


Years ago, Pregnenolone was found to help against rheumatoid arthritis, an autoimmune condition. Patients reported less pain and fatigue and more strength.

Who Should Take Pregnenolone?

I regard Pregnenolone as an unheralded team player that potentiates other hormones. I recommend it to anyone starting a total hormonal replacement program or who has memory or stamina problems. 

My main reason for using this hormone is that it occupies such a central position in the hormonal hierarchy. In addition to that 

By optimizing your pregnenolone levels, you will enjoy the following benefits:

  • A reduction of cholesterol levels
  • A boost in memory
  • An increase in social confidence
  • An occasional cognitive or intellectual boost
  • A relief in hangovers and a next-day remedy when you’ve had too little sleep
  • Less arthritis and joint pain

It also works to support any program for depression or severe PMS that hasn’t been totally resolved. Many times, Pregnenolone can generate the final extra degree of improvement.

How to Take Pregnenolone 

Pregnenolone can be found in 10 mg capsules.  Begin with 10, and every 3 days, increase your dose, so you feel energized and have mental clarity until you hit 50 mg.  You will notice you feel more socially brave and outgoing.   Higher doses are safe but not usually needed.

Reduce your dose the moment you feel agitated, nervous, or irritable.

Answer the following questions to find out if you may benefit from optimizing your pregnenolone levels.

Are you more forgetful lately?

Does your mind have trouble “rising” to a more challenging than usual mental task?

Are you not as sharp as you used to be, in general?

Do you no longer have the courage to share thoughts that are more controversial?

Is there a family history of Alzheimer’s disease?

Do you have high cholesterol?

If so, do you use statin medications to treat and control it?

Do you take anti-anxiety medication and experience difficulty getting going in the morning?

Do you have difficulty seeing colors clearly?

Are you feeling more depressed than usual?

Do you have arthritis, or do you experience joint pain?

Or, more generally, do you lack the vital physical energy you used to have?

If you identify with any of the conditions mentioned in these questions,

you should consider exploring whether you are producing suboptimal levels of pregnenolone. Following are some of the reasons you may benefit from optimizing your levels.

Unhealthy Stress – How your Adrenal Glands Can Affect Your Health

Unhealthy Stress – How your Adrenal Glands Can Affect Your Health

Unhealthy Stress – How your Adrenal Glands Can Affect Your Health 800 533 Abbe Lang

I realized last week that I may have been burning the candle at both ends. After a restful weekend, my body wanted to crash at about 4pm on Monday afternoon. I had went to the gym that day – well actually went to two gyms that day – and by late afternoon I felt extremely fatigued and achy. I didn’t have the symptoms of any type of flu but surely felt like I had the onset of some sort of flu virus coming on. It dawned on me that I had been pushing myself too hard and I was under a great amount of mental, emotional and physical stress for the past few months. My adrenal glands were not happy!

Looking back over the past few weeks and maybe even months, I realized the significant amount of stress that I was under left my cortisol levels too high. This can lead to disruptive sleep and days filled with caffeine cravings. In my case, this past week the added stress left me with lower cortisol levels, leaving my immune system exposed and overreacting to pathogens.

Support your Glands!

What Are Adrenal Glands Anyway?

The adrenal glands are a key organ system for managing fluid balance, managing inflammation and providing sustained energy throughout the day. The adrenals help you sail through the negative effects of stress, including emotional, mental and physical stress, and they fight fatigue and muscular weakness.

Today’s stressful lifestyles and poor “fast-food” dietary habits have a cumulative stressful effect on the adrenal glands. You may even find that your cravings for salty foods stem from your adrenals losing the ability to balance minerals like sodium, potassium and magnesium in your blood. In turn, this leads to cravings for foods which will replace the sodium that we have lost. Your ability to respond to stress well is directly affected by adrenal function. It directly affects your level of muscular strength, blood sugar levels, energy levels and sense of well being.

Symptoms of Adrenal Fatigue

  • Asthma
  • Dark Circles under the eyes
  • Dizziness
  • Dry Skin
  • Extreme Tiredness an hour after exercise
  • Frequent urination
  • Joint pain
  • Loss of muscle tone
  • Joint pain
  • Low blood pressure
  • Low sex drive
  • Lower back pain
  • Numbness in your fingers /Poor circulation
  • Weight gain

Stress Hormones

Stress hormones such as cortisol are produced and regulated by the adrenal glands. They are created to help the body to deal with stressful situations by increasing the heart rate and the force of contraction and blood flow to the heart, liver, skeletal and adipose tissue. They also dilate airways to the lungs and increase blood levels of glucose and fatty acids. Stress hormones and their effects are linked to virtually every body system. Thus, many physiological processes and bodily functions, including cardiovascular health, sex drive, pH balance, skin conditions, energy levels, mood and overall psychological outlook often correlate to adrenal gland function.

In my ebook Secrets of Weight Loss, Diet and Staying Lean Forever (which is also part of my Health & Beauty Bundle) I discuss foods to eat and avoid for healthy adrenal function.